Paulo de Andrade, JeanGiordani, R. B.Torras Claveria, LauraPigni, Natalia BelénBerkov, StrahilFont Bardia, Ma. MercedesCalvet Pallàs, Maria TeresaKonrath, E.Bueno, K.Sachett, L. G.Dutilh, J. H.Borges, W. D.Viladomat Meya, FrancescHenriques, A. T.Nair, Jerald J.Zuanazzi, José Ângelo SilveiraBastida Armengol, Jaume2020-06-022020-06-022016-021568-7767https://hdl.handle.net/2445/163721Nine Brazilian Amaryllidaceae species were studied for their alkaloid composition and acetylcholinesterase (AChE) inhibitory activity via GC-MS and a modified Ellman assay, respectively. A total of thirty-six alkaloids were identified in these plants, of which Hippeastrum papilio and H. glau-cescens exhibited the highest galanthamine content and the best IC50 values against AChE. Furthermore, Hippeastrum vittatum and Rhodophiala bifida also showed notable AChE inhibitory effects. X-ray crys-tallographic data for four galanthamine-type com-pounds revealed significant differences in the orientation of theN-methyl group, which are shown to be related to AChE inhibition.24 p.application/pdfeng(c) Springer Science + Business Media, 2016AlcaloidesRadiocristal·lografiaAlkaloidsX-ray crystallographyinfo:eu-repo/semantics/article6569742020-06-02info:eu-repo/semantics/openAccess