An integrin-targeted photoactivatable Pt(IV) complex as a selective anticancer pro-drug: synthesis and photoactivation studies

Gandioso, AlbertShaili, EvyeniaMassaguer i Vall-llovera, AnnaArtigas Solé, GerardGonzález-Cantó, AlejandroWoods, Julie A.Sadler, PeterMarchán Sancho, Vicente2015-10-082016-04-212015-04-281359-7345https://hdl.handle.net/2445/67182A new anticancer agent based on the conjugation of a photoactivatable Pt(IV) pro-drug to a cyclic RGD-containing peptide is described. Upon visible light irradiation, phototoxicity was induced preferentially in SK-MEL-28 melanoma cancer cells overexpressing alphaVbeta3 integrin compared to control DU-145 human prostate carcinoma cells.4 p.application/pdfeng(c) Gandioso, Albert et al., 2015Quimioteràpia del càncerCancer chemotherapyAn integrin-targeted photoactivatable Pt(IV) complex as a selective anticancer pro-drug: synthesis and photoactivation studiesinfo:eu-repo/semantics/article6519272015-10-08info:eu-repo/semantics/openAccess25947177