Georges, YohanAriza Piquer, XavierGarcía Gómez, Jordi2013-12-202013-12-2020090022-3263https://hdl.handle.net/2445/48632(-)-Spicigerolide was enantioselectively synthesized from a protected (S)-lactaldehyde. The synthesis of the polyacetylated framework relied on two Zn-mediated stereoselective additions of alkynes to aldehydes as well as a regiocontrolled [3,3]-sigmatropic rearrangement of an allylic acetate. The pyranone moiety was constructed via ring-closing metathesis.16 p.application/pdfeng(c) American Chemical Society , 2009PlantesBotànica mèdicaCitotoxicitat per mediació cel·lularCàncerEstereoquímicaProductes naturalsSíntesi orgànicaPlantsMedical botanyCell-mediated cytotoxicityCancerStereochemistryNatural productsOrganic synthesisinfo:eu-repo/semantics/article5659002013-12-20info:eu-repo/semantics/openAccess