Molina García, MariolaFraguas, DavidDel Rey Mejias, AngelMezquida Mateos, GiselaSánchez-Torres, Ana M.Amoretti Guadall, SilviaLobo, AntonioGonzález-Pinto, AnaAndreu-Bernabeu, ÁlvaroCorripio, IluminadaVieta i Pascual, Eduard, 1963-Baeza, Inmaculada, 1970-Mané Santacana, AnnaCuesta, Manuel J.Serna Gómez, Elena de laPayá, BeatrizZorrilla, IñakiArango, CelsoBernardo Arroyo, MiquelRapado-Castro, MartaParellada, MaraPEPs Group2022-03-172022-03-172021-06-022077-0383https://hdl.handle.net/2445/184200Background: premorbid IQ (pIQ) and age of onset are predictors of clinical severity and long-term functioning after a first episode of psychosis. However, the additive influence of these variables on clinical, functional, and recovery rates outcomes is largely unknown. Methods: we characterized 255 individuals who have experienced a first episode of psychosis in four a priori defined subgroups based on pIQ (low pIQ < 85; average pIQ ≥ 85) and age of onset (early onset < 18 years; adult onset ≥ 18 years). We conducted clinical and functional assessments at baseline and at two-year follow-up. We calculated symptom remission and recovery rates using the Positive and Negative Symptoms of Schizophrenia Schedule (PANSS) and the Global Assessment Functioning (GAF or Children-GAF). We examined clinical and functional changes with pair-wise comparisons and two-way mixed ANOVA. We built hierarchical lineal and logistic regression models to estimate the predictive value of the independent variables over functioning or recovery rates. Results: early-onset patients had more severe positive symptoms and poorer functioning than adult-onset patients. At two-year follow-up, only early-onset with low pIQ and adult-onset with average pIQ subgroups differed consistently, with the former having more negative symptoms (d = 0.59), poorer functioning (d = 0.82), lower remission (61% vs. 81.1%), and clinical recovery (34.1% vs. 62.2%). Conclusions: early-onset individuals with low pIQ may present persistent negative symptoms, lower functioning, and less recovery likelihood at two-year follow-up. Intensive cognitive and functional programs for these individuals merit testing to improve long-term recovery rates in this subgroup.19 p.application/pdfengcc-by (c) Molina García, Mariola et al., 2021https://creativecommons.org/licenses/by/4.0/PsicosiPronòstic mèdicPsychosesPrognosisinfo:eu-repo/semantics/article7144542022-03-17info:eu-repo/semantics/openAccess