Ramiro, LauraAbraira, LauraQuintana, ManuelGarcía Rodríguez, PaulaSantamarina, EstevoÁlvarez Sabín, JoseZaragoza, JosepHernández Pérez, MaríaUstrell, XavierLara, BlancaTerceño, MikelBustamante, AlejandroMontaner, Joan2021-03-262021-03-262021-02-10https://hdl.handle.net/2445/175800Stroke is a major cause of disability and death globally, and prediction of mortality represents a crucial challenge. We aimed to identify blood biomarkers measured during acute ischemic stroke that could predict long-term mortality. Nine hundred and forty-one ischemic stroke patients were prospectively recruited in the Stroke-Chip study. Post-stroke mortality was evaluated during a median 4.8-year follow-up. A 14-biomarker panel was analyzed by immunoassays in blood samples obtained at hospital admission. Biomarkers were normalized and standardized using Z-scores. Multiple Cox regression models were used to identify clinical variables and biomarkers independently associated with long-term mortality and mortality due to stroke. In the multivariate analysis, the independent predictors of long-term mortality were age, female sex, hypertension, glycemia, and baseline National Institutes of Health Stroke Scale (NIHSS) score. Independent blood biomarkers predictive of long-term mortality were endostatin > quartile 2, tumor necrosis factor receptor-1 (TNF-R1) > quartile 2, and interleukin (IL)-6 > quartile 2. The risk of mortality when these three biomarkers were combined increased up to 69%. The addition of the biomarkers to clinical predictors improved the discrimination (integrative discriminative improvement (IDI) 0.022 (0.007-0.048), p < 0.001). Moreover, endostatin > quartile 3 was an independent predictor of mortality due to stroke. Altogether, endostatin, TNF-R1, and IL-6 circulating levels may aid in long-term mortality prediction after stroke.11 p.application/pdfengcc by (c) Ramiro et al., 2021http://creativecommons.org/licenses/by/3.0/es/IsquèmiaMarcadors bioquímicsMortalitatIschemiaBiochemical markersMortalityinfo:eu-repo/semantics/article2021-03-24info:eu-repo/semantics/openAccess33578805