Bastard, PaulGervais, AdrianTaniguchi, MakiSaare, LiisaSärekannu, KaritaLe Voyer, TomPhilippot, QuentinRosain, JérémieBizien, LucyAsano, TakakiGarcia Prat, MarinaJouanguy, EmmanuelleTatsi, Elizabeth BarbaraRenia, LaurentCobat, AurélieSadiki Orayyou, José MiguelLendoiro Fuentes, MartaColobran, RogerResnick, IgorRodríguez Gallego, CarlosYahşi, AysunCastagnoli, RiccardoPan-Hammarström, QiangCasari, GiorgioVarela García, PabloBarbeito Castiñeiras, GemaDacosta Urbieta, Ana IsabelFilippatos, FilipposBen García, MiriamPrando, CarolinaHatipoglu, NevinBondarenko, AnastasiiaFroidure, AntoineViz Lasheras, SandraMironska, KristinaLópez Franco, MontserratVinh, Donald C.Rey García, SusanaCobat, AurélieTiberghien, PierreDuval, XavierFernández Villaverde, JuanBoisson, BertrandBiggs, Catherine M.Duvlis, SotirijaBousfiha, Ahmed A.Fellay, JacquesBastón Rey, IriaPesole, GrazianoSalas, AntonioZawadzki, PawelHammarström, LennartBéziat, VivienCondino Neto, AntonioPerez Tur, JordiConstantinescu, Stefan N.Hsieh, Elena W.y.Aguilera Guirao, AntonioBorghesi, AlessandroPession, AndreaRodriguez Palmero, AgustiCovid CliniciansItan, YuvalSaborido Paz, EvaEscoda, SimonGuerra Liñares, BeatrizRey Vázquez, SaraAndreakos, EvangelosFerreiro Iglesias, RocioPérez Freixo, HugoNúñez Masid, EloínaThorball, ChristianSeppänen, Mikko R.J.Mentré, FranceTancevski, IvanAhlijah, GloriaRivière, Jacques G.Ng, Lisa F.P.Gen Covid Study GroupNovelli, GiuseppeZatz, MayanaTrouillet Assant, SophieCovid Human Genetic EffortCoira Nieto, AmparoJabandziev, PetrCarral García, María VictoriaHayakawa, SeiichiCurrás Tuala, María JoséPerlin, David S.Soudee, CamilleArseguel, VincentGrimbacher, BodoLévy, RomainFurkan Uddin, K.M.Bousfiha, Ahmed A.Abolhassani, HassanOzcelik, TayfunLeboráns Iglesias, PilarBogunovic, DusanSahanic, SabinaSerén Fernández, SoniaRiveiro Blanco, VanessaGalbán Rodríguez, CristóbalGorochov, GuySoumelis, VassiliMilner, Joshua D.Tancevski, IvanNukui, YokoTüter Öz, Şadiye KübraHammarström, LennartO’farrelly, ClionaLau, Yu LungBrodin, PetterCondino Neto, AntonioOkada, SatoshiRivero Calle, IreneAiuti, AlessandroButte, Manish J.Neven, BénédicteSancho Shimizu, VanessaBolze, AlexandreGregersen, Peter K.Marseglia, Gian LuigiSoler Palacín, PereSlaby, OndrejKisand, KaiEl Bakkouri, JalilaTemel, Şehime GülsünMetin Akcan, OzgeDesai, MurkeshParra Martínez, AlbaTrastoy Pena, RocíoTurvey, Stuart E.Ozcelik, TayfunJavouhey, EtienneAbi Haidar, AnthonyErdeniz, Emine HafizeZhang, Shen YingKılıç, Ahmet OsmanSouto Sanmartín, PabloPujol, Aurora, 1968-Su, Helen C.Imai, KohsukeOzkaya Parlakay, AslinurPapadaki, MariaRivero Velasco, CarmenGiráldez Vázquez, ElenaQuartier, PierreMeyts, IsabelleSlaba, KaterinaLing, YunPardo Seco, JacoboOkamoto, KeisukeCebey López, MiriamHalwani, RabihBelot, AlexandreBryceson, YenanSoler Palacin, PereSchidlowski, LaireConde Pájaro, MónicaPischedda, SaraAbel, LaurentZhang, QianGulhan, BelginAlkan, GulsumGómez Carballa, AlbertoChristodoulou, JohnFranco, José LuisCasanova, Jean-LaurentRegueiro Casuso, PatriciaPortela Romero, ManuelMigaud, MélanieWauters, JoostKarbuz, AdemPose Reino, AntonioTillmann, ValloSediva, AnnaNavarro De La Cruz, DanielMarr, NicoPrada Hervella, Gloria MaríaMogensen, Trine H.Lucas, Carrie L.Drolet, Beth A.Husain, MayaMeyts, IsabelleQueiro Verdes, TeresaTangye, Stuart G.Redondo Collazo, LorenzoAnderson, Mark S.Martinón Torres, FedericoBayhan, Gülsün IclalSpaan, András N.Tandjaoui Lambiotte, YacineFernández Pérez, CristinaMansouri, DavoodPérez de Diego, RebecaVon Bernuth, HorstShahrooei, MohammedGarcía Vicente, LuisaBello Paderne, XabierAndreakos, EvangelosTipu, ImranTroya, JesusDomínguez Santalla, María JesúsTreviño Castellano, MercedesCheikh, NathalieArias, Andrés A.Gómez Rial, JoséOstrowski, Sisse RyeAlkhater, Suzan A.González Granado, Luis IgnacioMartinón Torres, FedericoHeath, James R.Arkin, Lisa M.Mentis, Alexios Fotios A.Abel, LaurentMorio, TomohiroKanik Yuksek, SalihaBaris Feldman, HagitGómez Carballa, AlbertoBastard, PaulMaródi, LászlóTanaka, JunkoPérez Del Molino Bernal, MarisaColobran, RogerBelot, AlexandreOkada, SatoshiAguilera Albesa, SergioNotarangelo, Luigi D.Zhang, QianCyrus, CyrilLence Massa, BeatrizÁlvarez Escudero, JuliánSaito Villanueva, CarlaMorio, TomohiroJarvis, Erich D.Chrousos, George P.Costa Alcalde, José JavierCalviño Suárez, CristinaEloy, PhilippineTrouillet Assant, SophieGarcía Allut, José LuisUddin, Mohammed J.Ku, Cheng LungShcherbina, AnnaJouanguy, EmmanuelleGonzález Barcala, Francisco JavierEmiroglu, MelikeAmara, AliHaerynck, FilomeenOrtolá Devesa, Juan BautistaHagin, DavidKaja, ElżbietaSevketoglu, EsraSnow, Andrew L.Mogensen, Trine H.Abou Tayoun, AhmadPazo Núñez, MaríaKaramitros, TimokratisRodríguez Tenreiro Sánchez, CarmenKisand, KaiPlanas, Anna M.Piñeiro Rodríguez, LidiaRoussel, LucieAl Muhsen, SalehMichos, AthanasiosDalgard, Clifton L.Espinosa Padilla, SaraPuel, AnneElmas Bozdemir, SefikaEl Baghdadi, JamilaBeek, Diederik Van DeKeles, SevgiRodríguez Núñez, NuriaCooper, Megan A.Tsumura, MiyukiNovelli, AntonioTaboada Muñiz, ManuelPrando, CarolinaRodríguez Gallego, CarlosValdés Cuadrado, LuisHaerynck, FilomeenDíaz Esteban, BlancaPeterson, PärtPujol, Aurora, 1968-Pape, Jean W.Valencia Ramos, JuanBrodin, PetterAl Mulla, FahdPuel, AnneQuintana Murci, LluisFlores, CarlosLópez Lago, AnaHusebye, EysteinAntela López, AntonioRamaswamy, SathishkumarConti, FrancescaSalas, AntonioVilas Iglesias, María Soledad2024-02-162024-02-162024-01-041540-9538https://hdl.handle.net/2445/207702We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-alpha 2 in 10 patients: IFN-alpha 2 only in three, IFN-alpha 2 plus IFN-omega in five, and IFN-alpha 2, IFN-omega plus IFN-beta in two; IFN-omega only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-alpha 2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-omega in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-alpha 2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-. only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-omega and/or IFN-alpha 2.45 p.application/pdfengcc by (c) Bastard, Paul et al., 2024http://creativecommons.org/licenses/by/3.0/es/AutoanticossosCOVID-19AutoantibodiesCOVID-19info:eu-repo/semantics/article2024-02-16info:eu-repo/semantics/openAccess38175961