Kudela, DamienSmith, Stephanie A.May Masnou, AnnaBraun, Gary B.Pallaoro, AlessiaNguyen, Chi K.Chuong, Tracy T.Nownes, SaraAllen, RileyParker, Nicholas R.Rashidi, Hooman H.Morrissey, James H.Stucky, Galen D.2015-02-112016-01-292015-01-290044-8249https://hdl.handle.net/2445/62752We present a silica nanoparticle (SNP) functionalized with polyphosphate (polyP) that accelerates the natural clotting process of the body. SNPs initiate the contact pathway of the blood-clotting system; short-chain polyP accelerates the common pathway by the rapid formation of thrombin, which enhances the overall blood-clotting system, both by accelerating fibrin generation and by facilitating the regulatory anticoagulation mechanisms essential for hemostasis. Analysis of the clotting properties of bare SNPs, bare polyP, and polyP-functionalized SNPs in plasma demonstrated that the attachment of polyP to SNPs to form polyP-SNPs creates a substantially enhanced synergistic effect that lowers clotting time and increases thrombin production at low concentrations. PolyP-SNP even retains its clotting function at ambient temperature. The polyP-SNP system has the potential to significantly improve trauma-treatment protocols and outcomes in hospital and prehospital settings.5 p.application/pdfeng(c) Wiley-VCH, 2015SiliciNanopartículesSilicatsFerides i lesionsHemorràgiaSiliconNanoparticlesSilicatesWounds and injuriesHemorrhageinfo:eu-repo/semantics/article6466082015-02-11info:eu-repo/semantics/openAccess25651530