Amat Tusón, MercedesFabregat, RobertGriera Farres, RosaFlorindo, PedroMolins i Grau, EliesBosch Cartes, Joan2019-01-172019-01-172010-03-310022-3263https://hdl.handle.net/2445/127382The straightforward enantioselective construction of the hydroquinoline ring system from 1,5-polycarbonyl derivatives, using (R)-phenyglycinol as a chiral latent form of ammonia, is reported. The process mimics the key steps believed to occur in nature in the biosynthesis of amphibian decahydroquinoline alkaloids. Diastereodivergent routes to enantiopure cis-2,5-disubstituted decahydroquinolines, including the alkaloid pumiliotoxin C (cis-195A), are developed.9 p.application/pdfeng(c) American Chemical Society , 2010BiosíntesiBiomimèticaSíntesi asimètricaSíntesi orgànicaBiosynthesisBiomimeticsAsymmetric synthesisOrganic synthesisBiomimetic Construction of the Hydroquinoline Ring System. Diastereodivergent Enantioselective Synthesis of 2,5-Disubstituted cis-Decahydroquinolinesinfo:eu-repo/semantics/article5793542019-01-17info:eu-repo/semantics/openAccess