Access to indolines from primary phenylethylamines by an unexpected palladium- catalyzed C-H functionalization process

Mancinelli, AndreaAlbert Mach, JoanAriza Piquer, XavierBarrios Moreno, Leoní AlejandraGarcía Gómez, JordiGómez, RobertoGranell Sanvicente, Jaime Ramón2019-09-182019-09-182019-08-292046-2069https://hdl.handle.net/2445/140436A new method for the preparation of 2,2-disubstituted indolines from 2-phenylethylamines was developed under Pd catalysis and PhI(OAc)2 as oxidant. Imines derived from 2-pyridinecarboxaldehyde were formed in situ to direct a C-H activation process. The resulting imines were also oxidized to the corresponding amides in the same Pd-catalyzed process to obtain the final indoline as a picolinamide.7 p.application/pdfengcc-by (c) Mancinelli, Andrea et al., 2019http://creativecommons.org/licenses/by/3.0/esPal·ladi (Element químic)CatàlisiPalladiumCatalysisAccess to indolines from primary phenylethylamines by an unexpected palladium- catalyzed C-H functionalization processinfo:eu-repo/semantics/article6912452019-09-18info:eu-repo/semantics/openAccess