Eills, JamesPicazo Frutos, RománBurueva, Dudari B.Kovtunova, Larisa M.Azagra, MarcMarco Rius, IreneBudker, DmitryKoptyug, Igor V.2023-09-132023-09-132023-07-142050-5620https://hdl.handle.net/2445/201920We show that catalyst-free aqueous solutions of hyperpolarized [1-13C]succinate can be produced using parahydrogen-induced polarization (PHIP) and a combination of homogeneous and heterogeneous catalytic hydrogenation reactions. We generate hyperpolarized [1-13C]fumarate via PHIP using para-enriched hydrogen gas with a homogeneous ruthenium catalyst, and subsequently remove the toxic catalyst and reaction side products via a purification procedure. Following this, we perform a second hydrogenation reaction using normal hydrogen gas to convert the fumarate into succinate using a solid Pd/Al2O3 catalyst. This inexpensive polarization protocol has a turnover time of a few minutes, and represents a major advance for in vivo applications of [1-13C]succinate as a hyperpolarized contrast agent.4 p.application/pdfengcc by-nc (c) Eills, James et al., 2023http://creativecommons.org/licenses/by-nc/3.0/es/HidrogenacióProcessos químicsHydrogenationChemical processesinfo:eu-repo/semantics/article2023-09-06info:eu-repo/semantics/openAccess660196437450281