Sánchez-Moya, AlbertPedroso Muller, EnriqueGrandas Sagarra, Anna2014-02-182014-12-3120131359-7345https://hdl.handle.net/2445/50383A novel method to synthesize cyclic oligonucleotides (5- to 26-mer) using the thiol-maleimide reaction is described. The target molecules were obtained after subsequent removal of thiol and maleimide protecting groups from 5′-maleimido-3′-thiol-derivatized linear precursors. Retro-Diels-Alder conditions deprotecting the maleimide simultaneously promoted cyclization cleanly and in high yield.3 p.application/pdfeng(c) Sánchez, Albert et al., 2013BioquímicaÀcids nucleicsBacterisMicrobiologiaCiclització (Química)BiochemistryNucleic acidsBacteriaMicrobiologyRing formation (Chemistry)info:eu-repo/semantics/article6199512014-02-18info:eu-repo/semantics/openAccess23183555