Solid-phase synthesis and DNA binding studies of dichloroplatinum(II) conjugates of dicarba analogues of octreotide as a new anticancer drugs

Barragán, FlaviaMoreno Martínez, VirtudesMarchán Sancho, Vicente2013-06-142013-06-1420091359-7345https://hdl.handle.net/2445/44244The first dichloroplatinum(II) conjugates of dicarba analogues of octreotide , which is expected to act as a"tumour-targeting device", have been efficiently synthesized following a stepwise solid-phase approach; these compounds emulate the mechanism of cisplatin since they form a 1,2-intrastrand cross-link with two consecutive guanines of an oligonucleotide.3 p.application/pdfeng(c) Barragán, Flavia et al., 2009ADNQuímica bioinorgànicaQuimioteràpia del càncerCèl·lules cancerosesToxicitat dels medicamentsDNABioinorganic chemistryCancer chemotherapyCancer cellsDrug toxicitySolid-phase synthesis and DNA binding studies of dichloroplatinum(II) conjugates of dicarba analogues of octreotide as a new anticancer drugsinfo:eu-repo/semantics/article5685222013-06-14info:eu-repo/semantics/openAccess