Rodríguez de Santiago, EnriquePérez de la Iglesia, SandraFrutos, Diego deMarín Gabriel, José CarlosMangas Sanjuan, CarolinaHonrubia López, RaúlUchima, HugoAicart Ramos, MartaRodríguez Gandía, Miguel ÁngelValdivielso Cortázar, EduardoRamos Zabala, FelipeAntonio Álvarez, MarcoSolano Sánchez, MarinaGonzález Santiago, Jesús ManuelAlbéniz, EduardoHijos Mallada, GonzaloCastro Quismondo, NereaFraile López, MiguelMartínez Ares, DavidTejedor Tejada, JavierHernández, LuisGornals, Joan B.Quintana Carbo, SergiOcaña, JuanCunha Neves, João A.Martínez Martínez, JuanLópez-Cerón Pinilla, MaríaDolz Abadía, CarlosPellisé Urquiza, MariaThe Mucosal Resection and Third-Space Endoscopy Working Group from the Spanish Society of Gastrointestinal Endoscopy2025-07-012025-07-012025-04-01https://hdl.handle.net/2445/221933Background: Delayed post-polypectomy bleeding (DPPB) is the most common adverse event following colonic polypectomy, yet its management remains highly heterogeneous and lacks standardization. A considerable number of colonoscopies performed for DPPB may be unnecessary and do not result in hemostatic intervention.Objectives: To develop evidence-based statements to guide clinical decision-making in DPPB.Design: Multidisciplinary Delphi consensus statement.Methods: A panel of 29 experts in gastroenterology, hematology, radiology, and surgery was assembled. Through a systematic review of the literature and a modified Delphi process, consensus statements were developed through iterative rounds of anonymous voting. Statements were revised following anonymous voting and feedback at each round. Those achieving 80% agreement were accepted.Results: The expert panel reached a consensus on 36 statements, covering areas such as antithrombotic management, bowel preparation, colonoscopy indications, and therapeutic hemostatic modalities. Key recommendations include guidance for managing self-limited bleeding and risk stratification to reduce the rate of unnecessary colonoscopies, as well as recommendations for hemodynamically unstable patients who may require primary angioembolization. A practical clinical algorithm is proposed.Conclusion: This document provides a consensus-based framework for managing DPPB. These recommendations aim to improve patient outcomes and optimize healthcare resources while fostering a standardized approach to this common adverse event.25 p.application/pdfengcc by-nc (c) Rodríguez de Santiago, Enrique et al., 2025http://creativecommons.org/licenses/by-nc/3.0/es/ColonoscòpiaHemorràgiaCirurgia colorectalcolonoscopyhemorrhageColorectal surgeryinfo:eu-repo/semantics/article2025-06-18info:eu-repo/semantics/openAccess