Novick, DiegoMontgomery, WilliamAguado, JaumePeng, XiaomeiHaro Abad, Josep Maria2017-05-292017-05-292016-04-111176-6328https://hdl.handle.net/2445/111703OBJECTIVE: To investigate the impact of anxiety symptoms on depression outcomes in Asian patients with major depressive disorder (MDD) (n=714). METHODS: The 17-item Hamilton Depression Scale (HAMD-17), overall severity, somatic symptoms, and quality of life (QOL) (EuroQOL Questionnaire-5 Dimensions [EQ-5D]) were assessed at baseline and 3 months. Anxiety was measured using items 10 and 11 from the HAMD-17. Linear, tobit, and logistic multiple regression models analyzed the impact of anxiety symptoms on outcomes. Baseline anxiety was related to age and the presence of pain symptoms at baseline. RESULTS: Regression models showed that a higher level of anxiety was associated with a lower frequency of remission and lower QOL at 3 months. Patients with lower baseline anxiety symptoms had higher remission rates (odds ratio for each point of anxiety symptoms, 0.829 [95% confidence interval [CI]: 0.723-0.951]). Patients with higher levels of baseline anxiety had a lower QOL at 3 months (a decrease in EQ-5D tariff score for each point of anxiety symptoms, 0.023 [95% CI: 0.045-0.001]). CONCLUSION: In conclusion, the presence of anxiety symptoms negatively impacts the outcomes of depression.6 p.application/pdfengcc-by-nc (c) Novick, Diego et al., 2016http://creativecommons.org/licenses/by-nc/3.0/esAnsietatDepressió psíquicaÀsiaAnxietyMental depressionAsiainfo:eu-repo/semantics/article6679482017-05-29info:eu-repo/semantics/openAccess27114710