Grau de Castro, Juan JoseCaballero Borrego, MiguelMackers Iglesias, PaulaReig Torras, OscarBuxo Orra, ElviraNavarrete Duran, PilarBlanch Andreu, JordiGrau Junyent, Josep M.2026-02-272026-02-272017-01-01Caballero, Miguel; Mackers, Paula; Reig, Oscar; Buxo, Elvira; Navarrete, Pilar; Blanch, Jose L; Grau, Juan J (2017). The Role of Audiometry prior to High-Dose Cisplatin in Patients with Head and Neck Cancer.. Oncology, 93(2), 75-82. DOI: 10.1159/000468522https://hdl.handle.net/2445/227589To analyze the role of audiometry in considering change to a less ototoxic treatment in head and neck cancer (HNC) patients.Consecutive patients prescribed high-dose cisplatin (100 mg/m2) between January 2013 and February 2015 were enrolled. Audiometry was performed at baseline and before cisplatin. Change to a less ototoxic agent or reduced cisplatin dose was considered with audiometric decreases >25 dB.A total of 103 patients were included; the median age of the patients was 59 years (range 18-75). Cisplatin was intended curative (58%), adjuvant (32%), or palliative (10%). Forty-two participants (41%) did not commence high-dose cisplatin because of baseline audiometric alterations. Of 61 patients treated with high-dose cisplatin, 40 (66%) showed marked ototoxicity at the end of treatment. The mean hearing loss between initial and final audiometries showed a hearing loss at 4 and 8 kHz in both ears (p = 0.002). Thirteen patients switched to carboplatin and 15 to a lower dose of cisplatin. The outcome was not significantly altered when cisplatin was replaced with carboplatin or cetuximab.Audiometric alterations are common in HNC with high-dose cisplatin, and switching to a less ototoxic regimen does not adversely affect outcome. Audiometric examination could help to prevent hearing loss in this population.© 2017 S. Karger AG, Basel.8application/pdfEnglishBiotecnologíaCancer researchCiências biológicas iCiências biológicas iiCiências biológicas iiiGeneral medicineMedicina iMedicina iiMedicina iiiMedicine (miscellaneous)OncologyQuímicaSaúde coletivaarticle2026-02-262831867