Martínez Yélamos, AntonioSaiz Hinarejos, AlbertSánchez del Valle Díaz, RaquelCasado Ruiz, VirginiaRamon Torrell, Josep M. (Josep Maria)Graus Ribas, FrancescArbizu Urdiain, Txomin2020-04-242020-04-242001-08-280028-3878https://hdl.handle.net/2445/157307Axonal damage probably occurs early in the evolution of MS. Five of 38 (13%) patients had a positive assay for the neuronal 14-3-3 protein in the CSF obtained at the first clinically isolated syndrome suggestive of MS. A positive 14-3-3 assay was the only independent predictor for a shorter time to conversion to clinical definite MS (risk ratio 4.1; 95% CI 1.1 to 15) and to reach an Expanded Disability Status Scale (EDSS) > or =2 at the end of follow-up (odds ratio 14.8; 95% CI 2.86 to 76.8). The detection of the 14-3-3 protein in the CSF at the first neurologic event suggestive of MS may be a useful predictor of short-term evolution.3 p.application/pdfeng(c) American Academy of Neurology, 2001Líquid cefalorraquidiEsclerosi múltipleProteïna-tirosina-fosfatasaCerebrospinal fluidMultiple sclerosisProtein-tyrosine phosphataseinfo:eu-repo/semantics/article5008702020-04-24info:eu-repo/semantics/openAccess11524491