Amador Palomar, MartaAriza Piquer, XavierBoyer, JérémieD'Andrea Rodríguez-Vida, LucíaGarcía Gómez, JordiGranell Sanvicente, Jaime Ramón2013-12-202013-12-2020100040-4039https://hdl.handle.net/2445/48627Chiral symmetrical alk-2-yne-1,4-diols have been stereoselectively transformed into 5-alkyl-4-alkenyl-4-phenyl-1,3-oxazolidin- 2-ones, which are precursors of quaternary α-amino β-hydroxy acids. The key step was the cyclization of the bis(tosylcarbamates) of 2- phenylalk-2-yne-1,4-diols, easily obtained from the starting chiral diols. These cyclizations were accomplished with complete regioselectivity and up to 92:8 dr in the presence of catalytic amounts of Ni(0) or Pd (II) derivatives under microwave heating.6 p.application/pdfeng(c) Elsevier Ltd, 2010Pal·ladi (Element químic)CatàlisiNíquelMicroonesEstereoquímicaPalladiumCatalysisNickelMicrowavesStereochemistryinfo:eu-repo/semantics/article5739762013-12-20info:eu-repo/semantics/openAccess