Prieto González, SergioDepetris, MarinaGarcía Martínez, AnaEspígol Frigolé, GeorginaTavera Bahillo, ItziarCorbera Bellalta, MarcPlanas Rigol, EsterAlba Garibay, Marco AntonioHernández Rodríguez, JoséGrau Junyent, Josep M. (Josep Maria)Lomeña Caballero, Francisco JuanCid Xutglà, M. Cinta2017-04-192017-04-192014-07-010003-4967https://hdl.handle.net/2445/109782BACKGROUND: Positron emission tomography (PET) scan is emerging as a promising imaging technique to detect large-vessel inflammation in giant cell arteritis (GCA). However, the lack of a standardised definition of arteritis based on (18)fluorodeoxyglucose (FDG) uptake is an important limitation to the use of PET scan for diagnostic purposes. OBJECTIVE: To prospectively assess the intensity and distribution of FDG uptake at different vascular territories in patients with newly diagnosed GCA compared with controls. METHODS: 32 consecutive, biopsy-proven, GCA patients treated with glucocorticoids for ≤3 days were included. The control group consisted of 20 individuals, who underwent PET/CT for cancer staging. Maximal standardised uptake value (SUVm) was calculated at four aortic segments, supraaortic branches and iliac-femoral territory. Sensitivity and specificity was calculated by receiver-operator characteristic curves (ROC) analysis. RESULTS: Mean SUVm was significantly higher in patients than in controls in all vessels explored and correlated with acute-phase reactants and serum IL-6. Mean of the SUVm at all the vascular territories had an area under the curve (AUC) of 0.830, and a cut-off of 1.89 yielded a sensitivity of 80% and a specificity of 79% for GCA diagnosis. There were no significant differences in AUC among the vascular beds examined. CONCLUSIONS: FDG uptake by large vessels has a substantial sensitivity and specificity for GCA diagnosis.6 p.application/pdfeng(c) BMJ Publishing Group, 2014Arteritis de cèl·lules gegantsCàncerInflamacióTomografia computada per emissió de fotó simpleEstudi de casosGiant cell arteritisCancerInflammationSingle-photon emission computed tomographyCase studiesinfo:eu-repo/semantics/article6428962017-04-19info:eu-repo/semantics/openAccess24665112