Hernández, SergiMoraga Llop, Fernando A.Díaz, A.de Sevilla, Mariona F.Ciruela, PilarMuñoz Almagro, CarmenCodina Grau, Maria GemmaCampins Martí, MagdaGarcía García, Juan JoséEsteva, CristinaIzquierdo, ConchitaGonzález Peris, SebastiàMartínez Osorio, JohannaUriona, SoniaSalleras i Sanmartí, LluísDomínguez García, Àngela2023-03-272023-03-272020-061080-6040https://hdl.handle.net/2445/196032Vaccination with the 13-valent conjugated pneumococcal disease (PCV13) has reduced invasive pneumococcal disease (IPD), but there have been reports of vaccine failures. We performed a prospective study in children aged 2-59 months who received diagnoses of IPD during January 2012-June 2016 in 3 pediatric hospitals in Catalonia, Spain, a region with a PCV13 vaccination coverage of 63%. We analyzed patients who had been age-appropriately vaccinated but who developed IPD caused by PCV13 serotypes. We detected 24 vaccine failure cases. The serotypes involved were 3 (16 cases); 19A (5 cases); and 1, 6B, and 14 (1 case each). Cases were associated with children without underlying conditions, with complicated pneumonia (OR 6.65, 95% CI 1.91-23.21), and with diagnosis by PCR (OR 5.18, 95% CI 1.84-14.59). Vaccination coverage should be increased to reduce the circulation of vaccine serotypes. Continuous surveillance of cases of IPD using both culture and PCR to characterize vaccine failures is necessary.9 p.application/pdfengDomini públic / Public domainhttps://creativecommons.org/publicdomain/mark/1.0/Reacció en cadena de la polimerasaEspanyaPneumococsVacunes antibacterianesPneumòniaInfeccions respiratòriesInfeccions per estreptococsVacunació dels infantsPolymerase chain reactionSpainStreptococcus pneumoniaBacterial vaccinesPneumoniaRespiratory infectionsStreptococcal infectionsVaccination of childreninfo:eu-repo/semantics/article7021122023-03-27info:eu-repo/semantics/openAccess