Demontis, DitteWalters, RaymondRajagopal, Veera M.Waldman, Irwin D.Grove, JakobAls, Thomas D.Dalsgaard, SorenRibasés Haro, MartaGrauholm, JonasBækvad-Hansen, MariaWerge, ThomasNordentoft, MereteMors, OleMortensen, Preben BoPsychiatric Genomics Consortium (PGC)Cormand Rifà, BruHougaard, David M.Neale, Benjamin M.Franke, BarbaraFaraone, Stephen V.Børglum, Anders D.2021-01-282021-01-282021-01-252041-1723https://hdl.handle.net/2445/173506Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood psychiatric disorder often comorbid with disruptive behavior disorders (DBDs). Here, we report a GWAS meta-analysis of ADHD comorbid with DBDs (ADHD + DBDs) including 3802 cases and 31,305 controls. We identify three genome-wide significant loci on chromosomes 1, 7, and 11. A meta-analysis including a Chinese cohort supports that the locus on chromosome 11 is a strong risk locus for ADHD + DBDs across European and Chinese ancestries (rs7118422, P = 3.15×10-10, OR = 1.17). We find a higher SNP heritability for ADHD + DBDs (h2SNP = 0.34) when compared to ADHD without DBDs (h2SNP = 0.20), high genetic correlations between ADHD + DBDs and aggressive (rg = 0.81) and anti-social behaviors (rg = 0.82), and an increased burden (polygenic score) of variants associated with ADHD and aggression in ADHD + DBDs compared to ADHD without DBDs. Our results suggest an increased load of common risk variants in ADHD + DBDs compared to ADHD without DBDs, which in part can be explained by variants associated with aggressive behavior.13 p.application/pdfengcc-by (c) Demontis, Ditte et al., 2021http://creativecommons.org/licenses/by/3.0/esTrastorns per dèficit d'atenció amb hiperactivitat en els infantsAgressivitat en els infantsAttention deficit disorder with hyperactivity in childrenAggressiveness in childreninfo:eu-repo/semantics/article6993822021-01-28info:eu-repo/semantics/openAccess33495439