Sánchez-Villegas, AlmudenaAlvarez Pérez, JacquelineToledo Atucha, EstefaníaSalas Salvadó, JordiOrtega Azorín, CarolinaZomeño Fajardo, María DoloresVioque, JesúsMartínez, J. Alfredo, 1957-Romaguera, DoraPérez López, JessicaLópez Miranda, JoséEstruch Riba, RamonBueno Cavanillas, AuroraArós, FernandoTur, Josep AntoniTinahones, Francisco J.Lecea, OscarMartín Sánchez, VicenteOrtega Calvo, ManuelVázquez, ClotildePintó Sala, XavierVidal i Cortada, JosepDaimiel, LidiaDelgado Rodríguez, MiguelMatía Martín, PilarCorella Piquer, DoloresDíaz López, AndrésBabio, NancyMuñoz Pérez, Miguel ÁngelFitó Colomer, MontserratGarcía de la Hera, ManuelaAbete, ItziarGarcía Ríos, AntonioRos Rahola, EmilioRuiz Canela, MiguelMartínez-González, Miguel Ángel, 1957-Izquierdo, MarisolSerra Majem, Lluís2020-04-262020-04-262018-12-182072-6643https://hdl.handle.net/2445/157577BACKGROUND: The aim of this analysis was to ascertain the type of relationship between fish and seafood consumption, omega-3 polyunsaturated fatty acids (ω-3 PUFA) intake, and depression prevalence. METHODS: Cross-sectional analyses of the PREDIMED-Plus trial. Fish and seafood consumption and ω-3 PUFA intake were assessed through a validated food-frequency questionnaire. Self-reported life-time medical diagnosis of depression or use of antidepressants was considered as outcome. Depressive symptoms were collected by the Beck Depression Inventory-II. Logistic regression models were used to estimate the association between seafood products and ω-3 PUFA consumption and depression. Multiple linear regression models were fitted to assess the association between fish and long-chain (LC) ω-3 PUFA intake and depressive symptoms. RESULTS: Out of 6587 participants, there were 1367 cases of depression. Total seafood consumption was not associated with depression. The odds ratios (ORs) (95% confidence intervals (CIs)) for the 2nd, 3rd, and 4th quintiles of consumption of fatty fish were 0.77 (0.63⁻0.94), 0.71 (0.58⁻0.87), and 0.78 (0.64⁻0.96), respectively, and p for trend = 0.759. Moderate intake of total LC ω-3 PUFA (approximately 0.5⁻1 g/day) was significantly associated with a lower prevalence of depression. CONCLUSION: In our study, moderate fish and LC ω-3 PUFA intake, but not high intake, was associated with lower odds of depression suggesting a U-shaped relationship.15 p.application/pdfengcc-by (c) Sánchez-Villegas, Almudena et al., 2018http://creativecommons.org/licenses/by/3.0/esAssaigs clínicsDepressió psíquicaÀcids grassos omega-3DietoteràpiaClinical trialsMental depressionOmega-3 fatty acidsDiet therapyinfo:eu-repo/semantics/article6877662020-04-26info:eu-repo/semantics/openAccess30567286