Degenhardt, FraukeEllinghaus, DavidJuzenas, SimonaLerga-Jaso, JonWendorff, MareikeMaya-Miles, DouglasUellendahl-Werth, FlorianElAbd, HeshamRühlemann, Malte C.Arora, JatinÖzer, OnurCaballero-Garralda, AndreaSolier, AuroraOmodei, PaoloBarretina, JordiPablo España, PedroMartinelli-Boneschi, FilippoD'Amato, MauroHeyckendorf, JanKaradeniz, ZehraBlay, NataliaLandmesser, UlfZheng, TenghaoProtzer, UlrikeTuset Gustad, LiseBonfanti, PaoloMay, SandraPontali, EmanueleGoerg, SiegfriedNafria-Jimenez, BeatrizHehr, UteGualtierotti, RobertaMyhre, RonnyCostantino, GiorgioSuwalski, PhillipHanses, FrankAugustin, MaxBraun, AliceOrtiz, Aaron BlandinoCavallero, AnnalisaGassner , ChristophFolseraas, TrineBellinghausen, CarlaScarpini, ElioParaboschi, Elvezia MariaBlasi, FrancescoTanck, AnjaContro, ErnestoRybniker, JanMüller, Karl ErikCherubini, AntonioYi, XiaoliKurth, FlorianManunta, MariaCiesek, SandraProtti, AlessandroBraun, NicoleFiguera Basso, Maria E.Mantovani, AlbertoSchröder, JuliaMartínez, NildaRodriguez Frias, FranciscoNöthen, Markus M.COVICAT study groupRojas, Itziar deTeles, AnaGerussi, AlessoAcosta-Herrera, MarialbertPumarola Suñé, TomàsKogevinas, ManolisSeilmaier, Michael J.Blanco-Grau, AlbertBujanda, LuisWesse, TanjaHelbig, Elisa T.Baldini, MarinaEgil Afset, JanWang, XiaominAghemo, AlessioHerr, ChristianTonby, KristianAmpuero, JavierMarsal, SaraGarcía Sánchez, FélixRipke, StephanSandoval, ElenaSancho, CristinaBellelli, GiuseppeFeldt, TorstenBettini, Laura RacheleJoannidis, MichaelHolten, Aleksander RyghAlbrecht, WolfgangAzuure, ClintonSpinner, Christoph D.Monzani, ValterSchaefer, BenediktFazaal, JuliaBandera, AlessandraMartín, JavierNieto, RosaHinney, AnkeBrenner, ThorstenBergan, JonasZoller, HeinzCáceres, MarioBocciolone, MonicaIntxausti, MaiderUrrechaga, EloisaGoikoetxea, JosuneScollo, ChiaraCecconi, MaurizioReverter, EnricWalter, JörnFerrando, CarlosMy, IlariaArana-Arri, EunateBombace, SaraPezzoli, GianniTomasi, MelissaRiveiro-Barciela, MarMesonero, FranciscoGuerrero, Juan M.Galvan Femenia, IvanPalom, AdrianaCeriotti, FerruccioBanales, Jesus M.Ruello, AntonellaRodrigues, Pedro M.Buti, MariaHeilmann-Heimbach, StefaniePreatoni, PaolettaSumoy, LauroPeter, WolfgangBrunak, SörenHeggelund, LarsKildal, Anders BenjaminAliberti, StefanoKlein, SebastianBacher, PetraKopfnagel, VerenaNavas, EnriqueGrasselli, GiacomoCardamone, GiuliaGonzalez Cejudo, TrinidadNkambule, LindokuhleHernandez-Tejero, MaríaJiménez, DavidValsecchi, Maria GraziaMüller, FrederikCortes, BeatrizGori, AndreaGarrido Chercoles, AdolfoCastoldi, MassimoBadalamenti, SalvatoriAzzolini, ElenaBahmer, ThomasEggermann, ThomasIllig, ThomasCid, Rafael deCarrabba, MariaKnopp, LisaLleo, AnaTentorio, PaoloBoada Rovira, M.Lehmann, ClaraAlbillos, AgustínTéllez, LuisRamirez, AlfredoSander, Leif ErikBiondi, AndreaHoffmann, PerLind, AndreasGarcia-Fernandez, Alba EstelaGalimberti, DanielaLenz, Tobias L.Schommers, PhilippRisnes, KariLihaug Hoff, Dag ArneFoti, GiuseppeSTORM Study group, The Humanitas Task Force, The Humanitas Gavazzeni Task ForceHemmrich-Stanisak, GeorgBals, RobertPoller, WolfgangBinatti, EleonoraMuscatello, AntonioMedrano, Francisco J.Bosari, SilvanoLatiano, AnnaCornberg, MarkusAsselta, RosannaDreher, MichaelMoreno Aguado, VíctorR Hov, JohannesAngelini, ClaudioAziz, FátimaIzquierdo-Sanchez, LauraFranke, AndreGarcia, FedericoMatullo, GiuseppeCazzaniga, MarinaHernández, IsabelPink, Isabellde Salazar, AdolfoSkogen, VegardRimoldi, ValeriaCarreras Nolla, AnnaMontano, NicolaCordioli, MattiaHeidecker, BettinaMa Dyrhol-Riise, AnnePigazzini, SaraKässens, JanBadia, Joan RamonNebel, AlmutGaede, Karoline I.Lippert, Lena J.Glück, AndreasHaschka, DavidSchaefer, MarcoGarbarino, LuciaCasalone, ElisabettaDelgado, JuanSchmidt, AxelSkurk, CarstenRoade, LuisaFarre, XavierOstadreza, MahnooshBerger, Marc M.Lange, ChristophLenning, Ole BerntMorilla, RubénQuereda, CarmenMarquié, MartaMateos, BeatrizLudwig, Kerstin U.Hu, CinziaKoehler, PhilippImaz Ayo, NataleVolland, SonjaKraft, JuliaRomero-Gómez, ManuelPrati, DanielleBianco, CristianaAlbano, GiovanniRando Segura, AriadnaPaccapelo, CinziaMalvestiti, FrancescoValenti, LucaMarx, NikolausCappadona, ClaudioBaselli, GuidoZanella, AlbertoMiozzo, MonicaDudman, SusanneTerranova, LeonardoJulià Cano, AntonioCastro Rebollo, PedroFaverio, PaolaMayer, AlenaBarreira, AnaChueca, NataliaGarcia-Etxebarria, KoldoKurth, IngoSchneider, JochenGutiérrez-Stampa, María A.Jensen, BjörnInvernizzi, PietroFernández Calles, JavierD'Angiò, MariellaPablo, Raúl deGallego-Durán, RocíoMartinelli-Boneschi, FilippoSantoro, LuigiHaider, SammraFracanzani, Anna LudovicaMuñiz-Diaz, EduardLudwig, NicoleKeitel, VerenaKurihara, HayatoPresenti, AntonioCiterio, GiuseppeHorra, C. de laNorwegian SARS-CoV-2 Study groupFriaza, VicenteDuga, StefanoErdmann, JeanettePalmieri, OrazioPestaña, DavidSchulte, Eva C.Ruiz, AgustínWienbrandt, LarsVadla, May SisselVehreschild, Maria J.G.T.Grimsrud, Marit M.Maj, CarloAndrade, VictorWitzke, OliverVoza, AntonioPeschuck, AnnaAachen Study (COVAS)Wacker, Eike M.Raychaudhuri, SoumyaFerrer, RicardToapanta, DavidCea, CristinaCiccarelli, MicheleRodríguez-Gandía, MiguelSchreiber, StefanDopazo, JoaquínDamås, Jan KristianPeyvandi, FloraAltmüller, JanineCalderón, Enrique J.Helbig, Elisa T.Witting, MichaelGanna, AndreaLamorte, GiuseppeCato Holter, JanCornely, Oliver A.Thibeault, CharlotteRosenstiel, PhilipNiemi, Mari E. K.Tran, FlorianPelusi, SerenaSolligård, ErikCarpani, RossanaMazzocco, MichelaKarlsen, Tom H.Bellani, GiacomoNeb, HolgerBanasik, KarinaKhodamoradi, YaschaWilfling, SibylleHernández Quero, José2023-06-012023-06-012022-12-010964-6906https://hdl.handle.net/2445/198771Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended genome-wide association meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a ~0.9-Mb inversion polymorphism that creates two highly differentiated haplotypes and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative including non-Caucasian individuals, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung.22 p.application/pdfengcc by-nc (c) Degenhardt, Frauke et al., 2022https://creativecommons.org/licenses/by-nc/4.0/deed.esCOVID-19Genoma humàGenèticaCOVID-19Human genomeGeneticsinfo:eu-repo/semantics/article7295512023-06-01info:eu-repo/semantics/openAccess35848942