Peris-Martínez, CristinaPiá-Ludeña, Jose VicenteRog-Revert, María JoséFernández-López, EsterDomingo i Pedrol, Joan Carles2023-05-192023-05-192023-03-062072-6643https://hdl.handle.net/2445/198246A prospective, randomized, single-center preliminary study was performed in patients with keratoconus stages I-III (Amsler-Krumeich), who received a high rich docosahexaenoic acid (DHA) (1000 mg/day) supplement for 3 months versus untreated patients. One eye per patient was evaluated. Thirty-four patients were recruited (75% men, mean age 31 years), with 15 randomized to the control group and 19 to the DHA-treated group. Corneal topography variables and plasma biomarkers of oxidative stress and inflammatory status were evaluated. A panel of fatty acids in blood samples was also assessed. There were significant between-group differences in the astigmatism axis, asphericity coefficient, and intraocular pressure in favor of the DHA group. Additionally, between-group significant differences in total antioxidant capacity (TAC), malondialdehyde (MDA), free glutathione (GSH) and GSH/GSSG ratio, as well as reduced values of inflammatory markers, including interleukin (IL)-4, IL-6, and vascular endothelial growth factor (VEGF-A) were found. These preliminary findings support the usefulness of the antioxidant and anti-inflammatory effects of DHA supplementation for targeting underlying pathophysiological mechanisms of keratoconus. Prolonged duration of DHA supplementation may be needed to detect more noticeable clinical changes in corneal topography.13 p.application/pdfengcc-by (c) Peris-Martínez, Cristina et al., 2023https://creativecommons.org/licenses/by/4.0/Estrès oxidatiuÀcids grassos omega-3Oxidative stressOmega-3 fatty acidsinfo:eu-repo/semantics/article7327632023-05-19info:eu-repo/semantics/openAccess