Koelsche, ChristianSchrimpf, DanielStichel, DamianSill, MartinSahm, FelixReuss, David E.Blattner, MirjamWorst, BarbaraHeilig, Christoph E.Beck, KatjaHorak, PeterMautner, Victor-FelixSchittenhelm, JensSerrano, JonathanSnuderl, MatijaBüttner, ReinhardKlingebiel, ThomasBuslei, RolfGessler, ManfredWesseling, PieterBrandner, SebastianJaunmuktane, ZaneDinjens, Winand N. M.Lyskjær, IbenSchirmacher, PeterStenzinger, AlbrechtBrors, BenediktGlimm, HannoHeining, ChristophTirado, Oscar M.Sáinz Jaspeado, Miguel GuillermoAlonso, JavierGarcía del Muro Solans, XavierMora Salvador, JaumeMoran, SebastianEsteller, Manel, 1968-Benhamida, Jamal K.Ladanyi, MarcWardelmann, EvaAntonescu, CristinaFlanagan, AdrienneDirksen, UtaBaumhoer, DanielHartmann, WolfgangHohenberger, PeterVokuhl, ChristianFlucke, UtaPetersen, IverMechtersheimer, GunhildCapper, DavidJones, David T. W.Fröhling, StefanPfister, Stefan M.Kreutzfeldt, SimonPaff, Elkevon Deimling, AndreasStark, SebastianJohann, PascalSelt, FlorianEcker, JonasSturm, DominikPajtler, Kristian W.Reinhardt, AnnekathrinWefers, Annika K.Sievers, PhilippSuwala, AbigailEbrahimi, AzadehFernández Klett, FranciscoCasalini, BelénKorshunov, AndreyHovestadt, VolkerKommoss, Felix K. F.Kriegsmann, MarkSchick, MatthiasBewerunge-Hudler, MelanieMilde, TillKulozik, Andreas E.Witt, OlafKool, MarcelRomero-pérez, LauraGrünewald, Thomas G. P.Kirchner, ThomasWick, WolfgangPlatten, MichaelUnterberg, AndreasUhl, MatthiasAbdollahi, AmirLehner, BurkhardDebus, JürgenThomas, ChristianHasselblatt, MartinPaulus, WernerHartmann, ChristianStaszewski, OriPrinz, MarcoHench, JürgenFrank, StephanVersleijen-Jonkers, Yvonne M. H.Mentzel, ThomasWeidema, Marije E.Griewank, KlausÁlava, Enrique deMartín, Juan DíazIdoate Gastearena, Miguel A.Chang, Kenneth Tou-EnLow, Sharon Yin YeeCuevas-Bourdier, AdrianMittelbronn, MichelMynarek, MartinSchüller, UlrichRutkowski, Stefan2021-02-252021-02-252021-01-21https://hdl.handle.net/2445/174293Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They represent a morphologically heterogeneous class of tumours and some entities lack defining histopathological features. Therefore, the diagnosis of sarcomas is burdened with a high inter-observer variability and misclassification rate. Here, we demonstrate classification of soft tissue and bone tumours using a machine learning classifier algorithm based on array-generated DNA methylation data. This sarcoma classifier is trained using a dataset of 1077 methylation profiles from comprehensively pre-characterized cases comprising 62 tumour methylation classes constituting a broad range of soft tissue and bone sarcoma subtypes across the entire age spectrum. The performance is validated in a cohort of 428 sarcomatous tumours, of which 322 cases were classified by the sarcoma classifier. Our results demonstrate the potential of the DNA methylation-based sarcoma classification for research and future diagnostic applications.10 p.application/pdfengcc by (c) Koelsche et al., 2021http://creativecommons.org/licenses/by/3.0/es/SarcomaADNSarcomaDNAinfo:eu-repo/semantics/article7161032021-02-25info:eu-repo/semantics/openAccess33479225