Holck Storås, AnneSanda, Martin G.Garín, OlatzChang, PeterPatil, DattatrayaCrociani, Catrina M.Suárez-Novo, José FranciscoCvancarova, MiladaHåvard Loge, JonFossa, Sophie D.2021-01-192021-01-192020-04-01https://hdl.handle.net/2445/173229Objective: To compare pre- and post-radical prostatectomy (RP) responses in the urinary incontinence domain of Expanded Prostate Cancer Index Composite-26 (EPIC-26) in cohorts from the USA, Norway and Spain. Methods: A prospective study of pre- and 1-year post-treatment responses in American (n=537), Norwegian (n=520) and Spanish (n=111) patients, establishing the prevalence of urinary incontinence defined according to published dichotomization. Thereafter we focused on the response alternatives "occasional dribbling", pad use and problem experience. A multivariate logistic regression analysis (significance level <= 0.01) considered risk factors for "not retaining total control". Results: Compared to the European men, the American patients were younger, healthier and more presented with lower risk tumors. Before RP no inter-country differences emerged the prevalence of urinary incontinence (6%). One-year post-treatment urinary incontinence was described by 30% of the American and 41% of the European patients, occasional dribbling being the most frequent type of urinary leakage. In the multivariate analysis the risk of "not retaining total control" increased almost 3-fold in European compared to American patients, with age and co-morbidity being additional independent risk factor. Conclusion: After RP patients from Spain and Norway reported more unfavorable outcomes by EPIC-26 than the American patients to most of the urinary incontinence items, the difference between the European and American patients remaining in the multivariate analysis. The most frequent post-RP response alternative "occasional dribbling" needs to be validated with pad weighing as "gold standard". (C) 2020 Editorial Office of Asian Journal of Urology. Production and hosting by Elsevier B.V.8 p.application/pdfengcc by-nc-nd (c) Editorial Office of Asian Journal of Urology, 2020http://creativecommons.org/licenses/by-nc-nd/3.0/es/Càncer de pròstataIncontinència urinàriaProstate cancerUrinary incontinenceinfo:eu-repo/semantics/article2020-12-21info:eu-repo/semantics/openAccess32257809