Mayor-Ruiz, CristinaWinter, Georg E.Koch, KerstinCiulli, AlessioThomä, Nicolas H.Dikic, Ivan2025-10-222025-10-222025-08-211097-2765https://hdl.handle.net/2445/223824In the past decade, exciting therapeutic strategies to harness the ubiquitin-proteasome system (UPS) for degradation of target proteins have emerged. Proximity-inducing modalities are at the center of these strategies and act by modulating protein-protein interactions. While we are still learning to harvest this approach, it holds tremendous promise for developing treatments for hitherto undruggable proteins. Here, we discuss how academic efforts and academic-industrial collaboration have advanced the development of therapeutic modalities based on the principle of roximity induction. We make a case for forming a global academia-industry alliance to enhance access to training and expertise while accelerating innovation and translation from ground-breaking ideas to proof of concept in the clinic.11 p.application/pdfengcc-by (c) Dikic, Ivan et al., 2025http://creativecommons.org/licenses/by/3.0/es/Telègraf òpticTelecomunicació en medicinaCol·laboració universitat-empresaOptical telegraphTelecommunication in medicineAcademic-industrial collaborationinfo:eu-repo/semantics/article2025-10-21info:eu-repo/semantics/openAccess674587540845803