Highly efficient, multigram and enantiopure synthesis of (S)-2-(2,4′-bithiazol-2-yl)pyrrolidine

Just Baringo, XavierBruno, PaoloAlbericio Palomera, FernandoÁlvarez Domingo, Mercedes2014-06-132014-06-132011-08-160040-4039https://hdl.handle.net/2445/54982(S)-2-(4-Bromo-2,4"-bithiazole)-1-(tert-butoxycarbonyl)pyrrolidine ((S)-1) was obtained as a single enantiomer and in high yield by means of a two-step modified Hantzsch thiazole synthesis reaction when bromoketone 3 and thioamide (S)-4 were used. Further conversion of (S)-1 into trimethyltin derivative (S)-2 broadens the scope for further cross-coupling reactions.3 p.application/pdfeng(c) Elsevier Ltd, 2011Productes naturalsAntibiòticsSíntesi de pèptidsCompostos heterocíclicsEnantiòmersNatural productsAntibioticsPeptide synthesisHeterocyclic compoundsEnantiomersHighly efficient, multigram and enantiopure synthesis of (S)-2-(2,4′-bithiazol-2-yl)pyrrolidineinfo:eu-repo/semantics/article5985122014-06-13info:eu-repo/semantics/openAccess