Lianza, MariacaterinaVerdan, Maria HelenaAndrade, Jean Paulo dePoli, FerruccioAlmeida, Larissa C. deCosta-Lotufo, Leticia V.Cunha Neto, ÁlvaroOliveira, Sarah C. C.Bastida Armengol, JaumeBatista, Andrea N. L.Batista Jr, João M.Borges, Warley S.2021-04-012021-04-012020-06-010103-5053https://hdl.handle.net/2445/175967The phytochemical study of Hippeastrum goianum led to the identification of 13 compounds by means of gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR). Compounds 7-demethoxy-9-O-methylhostasine (1) and 7-deoxi-trans-dihydronarciclasine (2) had their absolute configurations determined by vibrational circular dichroism (VCD). This is the first time that compound 1 is described in the Amaryllidaceae family. The cytotoxicity of all isolated compounds was tested against colorectal carcinoma (HCT 116), breast carcinoma (MCF-7), and non-tumor human retinal pigment epithelium (RPE) cell lines. The half-maximum inhibitory concentration (IC50) of compound 2 against each cell line was equivalent to the positive control (doxorubicin), indicating a considerable cytotoxic activity. Keywords: narciclasine; galasine; cytotoxic activity; absolute configuration; vibrational circular dichroism11 p.application/pdfengcc-by (c) Sociedade Brasileira de Química, 2020http://creativecommons.org/licenses/by/3.0/esAlcaloidesCitotoxicitat per mediació cel·lularDicroisme circularTumorsAlkaloidsCell-mediated cytotoxicityCircular dichroismTumorsinfo:eu-repo/semantics/article7101672021-04-01info:eu-repo/semantics/openAccess