Mir Morro, BartomeuSerrano, IsraelBuitrago Ospina, Diana CamilaOrozco López, ModestoEscaja Sánchez, NuriaGonzález, Carlos2017-11-102018-09-212017-09-210002-7863https://hdl.handle.net/2445/117632We report here the solution structure of several repetitive DNA sequences containing d(TCGTTCCGT) and related repeats. At physiological pH, these sequences fold into i-motif like quadruplexes in which every two repeats a globular structure is stabilized by two hemiprotonated C:C+ base pairs, flanked by two minor groove tetrads resulting from the association of G:C or G:T base pairs. The interaction between the minor groove tetrads and the nearby C:C+ base pairs affords a strong stabilization, which results in effective pHT values above 7.5. Longer sequences with more than two repeats are able to fold in tandem, forming a rosary bead-like structure. Bioinformatics analysis shows that these sequences are prevalent in the human genome, and are present in development-related genes.4 p.application/pdfeng(c) American Chemical Society , 2017OligonucleòtidsCromosomes humansGenètica humanaOligonucleotidesHuman chromosomesHuman geneticsinfo:eu-repo/semantics/article6736372017-11-10info:eu-repo/semantics/openAccess28933543