Sans de San Nicolàs, LídiaFigueras Nart, IgnasiBonfill-Ortí, MontserratDe Jesús-Gil, CarmenGarcía-Jiménez, IreneGuilabert, AntonioCurto-Barredo, LaiaBertolín-Colilla, MartaFerran, MartaSerra-Baldrich, EstherZalewska-Janowska, AnnaWang, Yui-HsiHowell, Michael D.Pujol Vallverdú, Ramón M.Santamaria Babí, Luis F.2024-11-122024-11-122022-110105-4538https://hdl.handle.net/2445/216418Staphylococcus aureus, memory skin-homing cutaneous lymphocyte-associated antigen (CLA)+ T cells and IL-13 constitute relevant players in atopic dermatitis (AD) pathogenesis.1 Since circulating CLA+ T cells reflect cutaneous abnormalities present in human inflammatory skin diseases,2 an ex vivo coculture model made of purified circulating CLA+/− effector and central memory T cells and autologous lesional epidermal cells was established. We show a CLA-dependent production of IL-13 upon activation with staphylococcal enterotoxin B (SEB) that allows the differentiation of the Th2 high and Th2 low groups, with distinct clinical correlations between both groups, within a clinically homogeneous population of adult non-treated moderate-to-severe AD patients.4 p.application/pdfengcc-by-nc (c) Sans de San Nicolàs, Lídia  et al., 2022http://creativecommons.org/licenses/by-nc/3.0/es/Staphylococcus aureusDermatitis atòpicaStaphylococcus aureusAtopic dermatitisinfo:eu-repo/semantics/article7307222024-11-12info:eu-repo/semantics/openAccess