Diz de Almeida, SilviaPujol Onofre, AuroraSCOURGE Cohort Group2025-08-292025-08-292024-02-142050-084Xhttps://hdl.handle.net/2445/222851The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we conducted a genome-wide association study (GWAS) for COVID-19 hospitalization in admixed Americans, comprising a total of 4702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations (BAZ2B and DDIAS). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in CREBBP. Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort. This study constitutes the largest GWAS for COVID-19 hospitalization in admixed Latin Americans conducted to date. This allowed to reveal novel risk loci and emphasize the need of considering the diversity of populations in genomic research.27 p.application/pdfengcc by (c) Diz de Almeida, Silvia et al, 2024http://creativecommons.org/licenses/by/3.0/es/Polimorfisme genèticCOVID-19Genetic polymorphismsCOVID-19info:eu-repo/semantics/article2025-08-26info:eu-repo/semantics/openAccess39361370