Lanaspa, MiguelBassat Orellana, QuiqueMedeiros, Marcia MeloMuñoz-Almagro, Carmen2017-07-212018-07-072017-07-071478-72101478-7210https://hdl.handle.net/2445/114190INTRODUCTION: The respiratory airways harbor a complex succession of ecological niches with distinct but related bacterial communities. Particular challenges of respiratory microbiome research have led to limited scientific output compared to other human microbiomes. Areas covered: In this review, we summarize the current state of knowledge of the bacterial respiratory microbiome, with a particular focus on associations between the respiratory microbiome and lower respiratory tract conditions. Expert commentary: There is growing evidence that the respiratory microbiome is associated with lower respiratory infectious diseases and related conditions. Most respiratory microbiome reports are metataxonomic cross-sectional or case-control studies with relatively small sample sizes. Large, prospective projects with metatranscriptomics or metabolomics approach are needed to unravel the effect of the respiratory microbiome on health-related conditions. Moreover, standardization in sampling, library preparation, sequencing techniques and data analysis should be encouraged.20 p.application/pdfeng(c) Taylor & Francis , 2017Malalties de l'aparell respiratoriBacterisRespiratory organs diseasesBacteriainfo:eu-repo/semantics/article2017-07-19info:eu-repo/semantics/openAccess