Ordeix i Utiel, SergiAlcaraz Argente, MartaLlor Brunés, NúriaCalbó Zabala, ArnauBosch Cartes, JoanAmat Tusón, Mercedes2020-05-272022-02-042020-02-040040-4020https://hdl.handle.net/2445/162698The stereocontrolled dialkylation at the carbonyl α-position of simple phenylglycinol-derived oxazolopiperidone lactams generates chiral scaffolds bearing a quaternary stereocenter, which are converted to acyclic quaternary stereocenter-containing chiral building blocks, such as 2,2-disubstituted 5-aminopentanols and 4,4-disubstituted O-protected 5-hydroxypentanoic acids and 5- hydroxypentanenitriles. The enantioselective synthesis of Kerr's intermediate, anadvanced synthetic precursor of the alkaloids of the leuconolam-leuconoxine-mersicarpine group, is reported from one of these aminopentanols14 p.application/pdfengcc-by-nc-nd (c) Elsevier B.V., 2020http://creativecommons.org/licenses/by-nc-nd/3.0/esLactamesAlcaloidesLactamsAlkaloidsinfo:eu-repo/semantics/article6998062020-05-27info:eu-repo/semantics/openAccess