Zamudio Vázquez, RubíIvanova, SaškaMoreno, MiguelHernández-Alvarez, María IsabelGiralt Lledó, ErnestBidon-Chanal Badia, AxelZorzano Olarte, AntonioAlbericio Palomera, FernandoTulla-Puche, Judit2020-05-042020-05-042015-05-202041-6520https://hdl.handle.net/2445/158574The synthesis of a new small library of quinoxaline-containing peptides is described. After cytotoxic evaluation in four human cancer cell lines, as well as detailed biological studies, it was found that the most active compound, RZ2, promotes the formation of acidic compartments, where it accumulates, blocking the progression of autophagy. Further disruption of the mitochondrial membrane potential and an increase in mitochondrial ROS was observed, causing cells to undergo apoptosis. Given its cytotoxic activity and protease-resistant features, RZ2 could be a potential drug candidate for cancer treatment and provide a basis for future research into the crosstalk between autophagy and apoptosis and its relevance in cancer therapy.13 p.application/pdfengcc-by (c) Zamudio Vázquez, Rubí et al., 2015http://creativecommons.org/licenses/by/3.0/es/QuinoxalinaPèptidsOncologiaRessonància magnètica nuclearSíntesi en fase sólidaQuímica combinatòriaQuinoxalinesPeptidesOncologyNuclear magnetic resonanceSolid-phase synthesisCombinatorial chemistryinfo:eu-repo/semantics/article6530362020-05-04info:eu-repo/semantics/openAccess