García Díaz, Anna I.Segura i Fàbregas, BàrbaraBaggio, Hugo CésarUribe, CarmeCampabadal Delgado, AnnaAbós, AlexandraMartí Domènech, Ma. JosepValldeoriola Serra, FrancescCompta, YaroslauBargalló Alabart, NúriaJunqué i Plaja, Carme, 1955-2020-05-202020-05-202017-11-071353-8020https://hdl.handle.net/2445/161619Background. Growing evidence highlights the relevance of posterior cortically-based cognitive deficits in Parkinson's disease (PD) as possible biomarkers of the evolution to dementia. Cross-sectional correlational studies have established a relationship between the degree of atrophy in posterior brain regions and visuospatial and visuoperceptual (VS/VP) impairment. The aim of this study is to address the progressive cortical thinning correlates of VS/VP performance in PD. Methods. Forty-four PD patients and 20 matched healthy subjects were included in this study and followed for 4 years. Tests used to assess VS/VP functions included were: Benton's Judgement of Line Orientation (JLOT), Facial Recognition (FRT), and Visual Form Discrimination (VFDT) Tests; Symbol Digit Modalities Test (SDMT); and the Pentagon Copying Test (PCT). Structural magnetic resonance imaging data and FreeSurfer were used to evaluate cortical thinning evolution. Results. PD patients with normal cognition (PD-NC) and PD patients with mild cognitive impairment (PD-MCI) differed significantly in the progression of cortical thinning in posterior regions. In PD-MCI patients, the change in VS/VP functions assessed by PCT, JLOT, FRT, and SMDT correlated with the symmetrized percent change of cortical thinning of occipital, parietal, and temporal regions. In PD-NC patients, we also observed a correlation between changes in FRT and thinning in parieto-occipital regions. Conclusion. In this study, we establish the neuroanatomical substrate of progressive changes in VS/VP performance in PD patients with and without MCI. In agreement with cross-sectional data, VS/VP changes over time are related to cortical thinning in posterior regions.32 p.application/pdfengcc-by-nc-nd (c) Elsevier B.V., 2018http://creativecommons.org/licenses/by-nc-nd/3.0/esImatges per ressonància magnèticaMalaltia de ParkinsonEscorça cerebralNeuropsicologiaMagnetic resonance imagingParkinson's diseaseCerebral cortexNeuropsychologyinfo:eu-repo/semantics/article6744352020-05-20info:eu-repo/semantics/openAccess29132765