Bachert, ClausHellings, Peter W.Mullol i Miret, JoaquimNaclerio, Robert M.Chao, JingdongAmin, NikhilGrabher, AnnetteSwanson, Brian N.Hamilton, Jennifer D.Guillonneau, SophieChristine TaniouZhang, DonghuiPirozzi, GianlucaGraham, Neil M. H.Staudinger, HeribertMannent, Leda P.Khan, Asif2020-03-032020-03-032019-03-272213-2198https://hdl.handle.net/2445/151860Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory condition affecting the upper airways, with chronic symptoms such as nasal congestion, partial (hyposmia) or total (anosmia) loss of smell, anterior/posterior rhinorrhea, and mild facial pain.1 As many as 66% of patients with CRSwNP have comorbid asthma and suffer from more severe nasal obstruction, higher levels of lower airway inflammation, and worse asthma control than those without CRS.2, 3 Thus, patients with CRSwNP and comorbid asthma have a high disease burden, seriously impacting health-related quality of life (HRQoL).2, 3 Markers of type 2-mediated inflammation and antibody production (eg, IL-5, IgE) are associated with both CRSwNP and asthma pathogenesis.25 p.application/pdfengcc by-nc-nd (c) Bachert et al., 2019http://creativecommons.org/licenses/by-nc-nd/3.0/es/AsmaSinusitisAsthmaSinusitisinfo:eu-repo/semantics/article2020-03-02info:eu-repo/semantics/openAccess489905830928658