Kennington, Stuart C. D.Teloxa, Saul F.Mellado Hidalgo, MiguelGaleote, OriolPuddu, SabrinaBellido, MarinaRomea, PedroUrpí Tubella, FèlixAullón López, GabrielFont Bardia, Ma. Mercedes2021-07-092021-07-092021-07-051433-7851https://hdl.handle.net/2445/178957A direct and asymmetric aldol reaction of N-acylthiazinanethiones with aromatic aldehydes catalyzed by chiralnickel(II) complexes is reported. The reaction gives thecorresponding O-TIPS-protected anti-aldol adducts in highyields and with remarkable stereocontrol and atom economy.Furthermore, the straightforward removal of the achiralscaffold provides enantiomerically pure intermediates ofsynthetic interest, which involve precursors for anti-a-amino-b-hydroxy anda,b-dihydroxy carboxylic derivatives. Theoret-ical calculations explain the observed high stereocontrol.6 p.application/pdfengcc-by-nc-nd (c) Kennington et al, 2021http://creativecommons.org/licenses/by-nc-nd/3.0/es/Reacció aldòlicaSíntesi asimètricaNíquelAldol reactionAsymmetric synthesisNickelinfo:eu-repo/semantics/article7130602021-07-09info:eu-repo/semantics/openAccess33872449