Piccichè, MiriamPinto, AlexandreGriera Farres, RosaBosch Cartes, JoanAmat Tusón, Mercedes2023-02-232023-07-182022-07-181523-7060https://hdl.handle.net/2445/194024Starting from (R)-phenylglycinol-derived tricyclic lactam 1, the enantioselective synthesis of (−)-cylindricine H is reported. From the stereochemical standpoint, the key steps are the stereoselective generation of the quaternary C10 stereocenter, the stereoselective introduction of the C4 acetoxy and C2 butyl substituents taking advantage of the lactam carbonyl functionality, and the assembly of the pyrrolidine ring with the required functionalized one-carbon chain at C13 by intramolecular opening of an epoxide.5 p.application/pdfeng(c) Miriam Piccichè, et al., 2022http://creativecommons.org/licenses/by-nc-nd/3.0/es/Síntesi asimètricaLactamesCatàlisi asimètricaAsymmetric synthesisLactamsEnantioselective catalysisinfo:eu-repo/semantics/article7256302023-02-23info:eu-repo/semantics/openAccess