Pereira, Licia P.Köhler, Cristiano A.Sousa, Rafael T.Solmi, MarcoFreitas, Bárbara P. deFornaro, MicheleMachado-Vieira, RodrigoMiskowiak, Kamilla W.Vieta i Pascual, Eduard, 1963-Veronese, NicolaStubbs, BrendonCarvalho, André F.2018-10-162019-07-012017-08-010149-7634https://hdl.handle.net/2445/125372Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder (BD). Nevertheless, findings have been inconsistent across studies. A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases from inception until January 9th, 2017. Forty-four studies met eligibility criteria (N=2122 BD participants). Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach. Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers. This review underscores the potential of gene-neuroimaging paradigms to provide mechanistic insights for BD. However, this systematic review found a single replicated finding. Suggestions to improve the reproducibility of this emerging field are provided, including the adoption of a trans-diagnostic approach61 p.application/pdfengcc-by-nc-nd (c) Elsevier, 2017http://creativecommons.org/licenses/by-nc-nd/3.0/esTrastorn bipolarImatges per ressonància magnèticaCervellManic-depressive illnessMagnetic resonance imagingBraininfo:eu-repo/semantics/article6715012018-10-16info:eu-repo/semantics/openAccess28479278