Synthesis of (E)-4-bromo-3-methoxybut-3-en-2-one, the key fragment in the polyhydroxylated chain common to oscillariolide and phormidolides A-C

Gil, AlejandroLamariano Merketegi, JanireLorente Crivillé, AdrianaAlbericio Palomera, FernandoÁlvarez Domingo, Mercedes2016-05-192017-05-172016-05-170947-6539https://hdl.handle.net/2445/98695The terminal bromomethoxydiene (BMD) moiety of the polyhydroxylated chain present in phormidolides and oscillariolides has been synthesized for first time. Several strategies for the stereoselective synthesis of the 4-bromo-3-methoxybut-3-en-2-ones are described. Furthermore, a preliminary study to successfully introduce this fragment within the polyol chain and introduction of the fatty acid allowed corroborate the end structure of the polyol.3 p.application/pdfeng(c) Wiley-VCH, 2016Productes naturalsSíntesi asimètricaQuímica orgànicaNatural productsAsymmetric synthesisOrganic chemistrySynthesis of (E)-4-bromo-3-methoxybut-3-en-2-one, the key fragment in the polyhydroxylated chain common to oscillariolide and phormidolides A-Cinfo:eu-repo/semantics/article6584552016-05-19info:eu-repo/semantics/openAccess26998826