Pérez, LourdesSabaté Pes, AntoniGutierrez, RosaCaballero Milán, MartaPujol, RogerLlaurado, SandraPeñafiel, JudithHereu, PilarBlasi Ibáñez, Annabel2024-10-142024-10-142024-08-162045-2322https://hdl.handle.net/2445/215736To explore preoperative and operative risk factors for red blood cell (RBC) transfusion requirements during liver transplantation (LT) and up to 24 h afterwards. We evaluated the associations between risk factors and units of RBC transfused in 176 LT patients using a log-binomial regression model. Relative risk was adjusted for age, sex, and the model for end-stage liver disease score (MELD) (adjustment 1) and baseline hemoglobin concentration (adjustment 2). Forty-six patients (26.14%) did not receive transfusion. Grafts from cardiac-death donors were used in 32.61% and 31.54% of non-transfused and transfused patients, respectively. The transfused group required more reoperation for bleeding (P = 0.035), longer mechanical ventilation after LT (P < 0.001), and longer ICU length of stay (P < 0.001). MELD and hemoglobin concentrations determined RBC requirements. For each unit of increase in the MELD score, 2% more RBC units were transfused, and non-transfusion was 0.83-fold less likely. For each 10-g/L higher hemoglobin concentration at baseline, 16% less RBC transfused, and non-transfusion was 1.95-fold more likely. Ascites was associated with 26% more RBC transfusions. With an increase of 2 mm from the baseline in the A10Fibtem measurement of maximum clot firmness, non-transfusion was 1.14-fold more likely. A 10-min longer cold ischemia time was associated with 1% more RBC units transfused, and the presence of post-reperfusion syndrome with 45% more RBC units. We conclude that preoperative correction of anemia should be included in LT. An intervention to prevent severe hypotension and fibrinolysis during graft reperfusion should be explored.10 p.application/pdfengcc by-nc-nd (c) Pérez, Lourdes et al, 2024http://creativecommons.org/licenses/by-nc-nd/3.0/es/Transfusió de sangTrasplantament hepàticBlood transfusionHepatic transplantationinfo:eu-repo/semantics/article2024-10-03info:eu-repo/semantics/openAccess39152310