Whelan, RoryMayor Ruiz, Cristina2024-04-022024-08-162024-02-161545-9985https://hdl.handle.net/2445/209323Ubiquitination is an essential process that curtails cellular levels of damaged and redundant proteins. Chemical biologists have harnessed this natural system to induce the degradation of disease-relevant proteins. We reflect here on the potential of ‘degraders’ for targeted selectivity, and discuss the role of computer-aided drug design in shaping future advances.3 p.application/pdfeng(c) Springer Nature, 2024Disseny de medicamentsModificació química de les proteïnesDrug designChemical modification of proteinsinfo:eu-repo/semantics/article2024-03-27info:eu-repo/semantics/openAccess660842438366231