Metachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database

Prospective Lynch Syndrome DatabaseCapella, GabrielPineda Riu, MartaDueñas, NuriaBrunet, Joan2025-07-082025-07-082025-03-281365-2168https://hdl.handle.net/2445/222101This first prospective observational study evaluates the impact of extended versus segmental colorectal surgery on the risk of metachronous colorectal cancer (CRC) in patients with Lynch syndrome, analyzing data from the Prospective Lynch Syndrome Database version 5. Extended resection significantly reduced the risk of metachronous CRC in path_MLH1, path_MSH2, and path_MSH6 carriers compared to segmental resection.11 p.application/pdfengcc by (c) Prospective Lynch Syndrome Database, 2025http://creativecommons.org/licenses/by/3.0/es/Cirurgia colorectalCàncer colorectalColorectal cancerColorectal surgeryMetachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Databaseinfo:eu-repo/semantics/article2025-06-19info:eu-repo/semantics/openAccess40231433