Alho, Daniela P.S.Salvador, Jorge A.R.Cascante i Serratosa, MartaMarín Martínez, Silvia2020-02-122020-02-122019-02-201420-3049https://hdl.handle.net/2445/150092A new series of glycyrrhetinic acid derivatives has been synthesized via the introduction of different heterocyclic rings conjugated with an α,β-unsaturated ketone in its ring A. These new compounds were screened for their antiproliferative activity in a panel of nine human cancer cell lines. Compound 10 was the most active derivative, with an IC50 of 1.1 µM on Jurkat cells, which is 96-fold more potent than that of glycyrrhetinic acid, and was 4-fold more selective toward that cancer cell line. Further biological studies performed in Jurkat cells showed that compound 10 is a potent inducer of apoptosis that activates both the intrinsic and extrinsic pathways.21 p.application/pdfengcc-by (c) Alho, Daniela P.S. et al., 2019http://creativecommons.org/licenses/by/3.0/esApoptosiCàncerApoptosisCancerinfo:eu-repo/semantics/article6872612020-02-12info:eu-repo/semantics/openAccess