Barceló, AntoniaEsquinas López, CristinaRobles, JuanPiérola, JavierPeña, Mónica de laAguilar, IreneMorell-Garcia, DanielAlonso, AlbertoToledo Pons, NuriaSánchez de la Torre, ManuelBarbé, Ferran2018-03-262018-03-262016-10-011389-9457https://hdl.handle.net/2445/121109Background: obstructive sleep apnea (OSA) is now being recognized as an additional contributing factor to the pathogenesis of obesity-related comorbidities. At the same time, there is now increasing evidence to suggest that intestinal wall permeability plays a role in the development of metabolic syndrome. In the present study, circulating zonulin and fatty acid binding protein (I-FABP) were measured in association with metabolic, hepatic, and inflammatory parameters. Results: compared with controls, plasma I-FABP levels were significantly higher in patients with OSA (571 pg/mL [IQR 290-950] vs 396 pg/mL [IQR 234-559], p = 0.04). Zonulin levels were similar between groups. Significant relationships were observed between zonulin levels and waist circumference (p < 0.05), glucose (p < 0.05), and insulin (p < 0.05). In addition, in the OSA group, zonulin levels correlated negatively with the mean nocturnal oxygenation saturation (p < 0.05) and positively with total cholesterol (p < 0.05), alanine aminotransferase (ALT) (p < 0.005), aminotransferase (AST) (p < 0.01), gamma glutamyltransferase (GGT) (p < 0.005), and high-sensitivity C-reactive protein (hs-CRP) (p < 0.05). Multivariate analysis showed that associations between zonulin and ALT, AST, and hs-CRP were attenuated, but not eliminated, after adjustment for other variables. Conclusions: the results of this study suggest that OSA is a risk factor for intestinal damage, regardless of metabolic profile, and that intestinal permeability might be a possible contributor to nonalcoholic fatty liver disease in patients with OSA.4 p.application/pdfengcc-by-nc-nd (c) Elsevier B.V., 2016http://creativecommons.org/licenses/by-nc-nd/3.0/esProteïnes portadoresFixació de proteïnesSíndrome metabòlicaAbsorció intestinalSíndromes d'apnea del sonObesitatCarrier proteinsProtein bindingMetabolic syndromeIntestinal absorptionSleep apnea syndromesObesityinfo:eu-repo/semantics/article6788382018-03-26info:eu-repo/semantics/openAccess28007354