Kapun, MiaPatel, RoshanPark, MahriPérez Areales, Francisco JavierKostadinova, Kristina A.Wharton, ThomasCarroll, Jason S.Spring, David R.2025-12-162025-12-162025-10-281359-7345https://hdl.handle.net/2445/224959Herein we describe the development of a novel azobenzene-containing glutathione-cleavable linker for use in antibody–drug conjugates (ADCs). This linker demonstrated efficient payload release under elevated glutathione levels while maintaining stability in human plasma. An anti-HER2 ADC incorporating this linker exhibited potent <em>in vitro</em> cytotoxicity and selective activity towards HER2-positive cell lines.4 p.application/pdfengcc-by (c) Mia Kapun et al., 2025http://creativecommons.org/licenses/by/4.0/FotofarmacologiaSíntesi de pèptidsEstrès oxidatiuGlutatióPhotopharmacologyPeptide synthesisOxidative stressGlutathioneinfo:eu-repo/semantics/article7629282025-12-16info:eu-repo/semantics/openAccess