Evidence of association of the NLRP1 gene with giant cell arteritis

Serrano, AuroraCarmona, F. DavidCastañeda, SantosSolans, RoserHernández Rodríguez, JoséCid Xutglà, M. CintaPrieto González, SergioMiranda-Filloy, José A.Rodríguez-Rodríguez, LuisMorado, Inmaculada C.Gómez Vaquero, CarmenBlanco, RicardoSopeña, BernardoOrtego Centeno, NorbertoUnzurrunzaga, AinhoaMarí-Alfonso, BegoñaSánchez-Martin, JulioGarcía-Villanueva, María JesúsHidalgo-Conde, AnaPazzola, GiuliaBoiardi, LuigiSalvarani, CarloGonzález-Gay, Miguel A.Martín, Javier2017-06-192017-06-192013-040003-4967https://hdl.handle.net/2445/112543Recent studies have focused attention on the involvement of NLRP1 to confer susceptibility for extended autoimmune/inflammatory disorders, being considered a common risk factor in autoimmunity. NLRP1 provides a scaffold for the assembly of the inflammasome that activates caspases 1 and 5, required for processing and activation of the proinflammatory cytokines interleukin 1β (IL-1β), IL-18 and IL-33 and promoting inflammation.3 p.application/pdfeng(c) BMJ Publishing Group, 2013Arteritis de cèl·lules gegantsPolimorfisme genèticGenèticaGiant cell arteritisGenetic polymorphismsGeneticsEvidence of association of the NLRP1 gene with giant cell arteritisinfo:eu-repo/semantics/article6410762017-06-19info:eu-repo/semantics/openAccess23253924