Extending the substrate scope in the hydrogenation of unfunctionalized tetrasubstituted olefins with Ir-P stereogenic aminophosphine-oxazoline catalysts

Biosca, MariaSalomó i Prat, ErnestCruz Sánchez, Pol de laRiera i Escalé, AntoniVerdaguer i Espaulella, XavierPàmies, OscarDiéguez, Montserrat2019-03-012020-01-162019-01-161523-7060https://hdl.handle.net/2445/129449Air stable and readily available Ir-catalyst precursors modified with MaxPHOX-type ligands have been successfully applied in the challenging asymmetric hydrogenation of tetrasubstituted olefins under mild reaction conditions. Gratifyingly, these catalyst precursors are not only able to efficiently hydrogenate a range of indene derivatives (ee's up to 96%) but also 1,2-dihydro-napthalene derivatives and acyclic olefins (ee's up to 99%), which both constitute the most challenging substrates for this transformation.5 p.application/pdfeng(c) American Chemical Society , 2019HidrogenacióCatàlisiLligands (Bioquímica)HydrogenationCatalysisLigands (Biochemistry)Extending the substrate scope in the hydrogenation of unfunctionalized tetrasubstituted olefins with Ir-P stereogenic aminophosphine-oxazoline catalystsinfo:eu-repo/semantics/article6865302019-03-01info:eu-repo/semantics/openAccess