Terrazas Martínez, MontserratAviñó Andrés, AnnaSiddiqui, Maqbool A.Marquez, Victor E.Eritja i Casadellà, Ramon2021-08-312021-08-312011-05-091523-7060https://hdl.handle.net/2445/179783An efficient method for the preparation of siRNAs modified with ribo-like North bicyclo[3.1.0]hexane pseudosugars is described. The combined use of 2'-O-(2-cyanoethoxymethyl) (CEM) and 2'-O-TBDMS protection was successfully employed for RNA synthesis with the added advantage that both groups were efficiently removed in a single step. The resulting North ribo-methanocarba-modified siRNAs are compatible with the intracellular RNAi machinery and can mediate specific degradation of target mRNA.4 p.application/pdfeng(c) American Chemical Society , 2011RNANucleòsidsEstructura molecularRNANucleosidesMolecular structureinfo:eu-repo/semantics/article7134322021-08-31info:eu-repo/semantics/openAccess