Baena, EstherGandarillas, AlbertoVallespinós, MireiaZanet, JenniferBachs Valldeneu, OriolRedondo, ClaraFabregat Romero, IsabelMartinez-A., CarlosMoreno de Alboran, Ignacio2023-02-242023-02-242005-05-170027-8424https://hdl.handle.net/2445/194142The c-Myc protein is a transcription factor implicated in the regulation of multiple biological processes, including cell proliferation, cell growth, and apoptosis. In vivo overexpression of c-myc is linked to tumor development in a number of mouse models. Here, we show that perinatal inactivation of c-Myc in liver causes disorganized organ architecture, decreased hepatocyte size, and cell ploidy. Furthermore, c-Myc appears to have distinct roles in proliferation in liver. Thus, postnatal hepatocyte proliferation does not require c-Myc, whereas it is necessary for liver regeneration in adult mice. These results show novel physiological functions of c-myc in liver development and hepatocyte proliferation and growth.6 p.application/pdfengcc-by-nc-nd (c) Baena, Esther et al., 2005http://creativecommons.org/licenses/by-nc-nd/3.0/es/Cèl·lulesFactors de transcripcióCicle cel·lularFetgeProliferació cel·lularCellsTranscription factorsCell cycleLiverCell proliferationinfo:eu-repo/semantics/article5568452023-02-24info:eu-repo/semantics/openAccess15857952